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The Editors

[long_description] As the end of the year approaches, the editors are delighted to present our second annual review, highlighting the essays that best represent our aims, ambitions, attitudes, and even our animadversions. Collected here are some notable essays we published this year, some illuminating exchanges from our letters section, and a selection of our favorite links from The Rambler.

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Thunder Out of China

Yuri Deigin

[short_description] Questions about the origins of COVID-19 are of more than academic interest. For the moment, the best explanation seems to be that the virus escaped from the Wuhan Institute of Virology.

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A Christmas Chrestomathy

The Editors

[short_description] As the year draws to a close, we are delighted to present our second annual Christmas Chrestomathy, highlighting the essays that best represent our aims, ambitions, attitudes, and even our animadversions.

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Outsmarting the Virus

John Hewitt

[short_description] Variants in the SARS-CoV-2 virus control infectivity, severity, and immunity. Against this hydra, the best modes of defense are multipronged. John Hewitt takes stock of currently available therapies.

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Expertise Unheeded

George Scialabba

[short_description] In responding to pandemics, members from the middle levels of the US government have tried, usually futilely, to get the appointees above them to do the right thing, or merely to pay attention.

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Battlefield Medicine

Benjamin Davido

[short_description] The AstraZeneca debacle in France, at the least, showed that to stop vaccinating for 48–72 hours in the name of the precautionary principle is to restart work on vaccine awareness from scratch.

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On the Futility of Contact Tracing

Jay Bhattacharya & Mikko Packalen

[short_description] Contact tracing may be useful when the number of cases in an epidemic is very small, and only if it is applied aggressively. In cases that do not fit this description, it may make an outbreak worse.

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The COVID Conversation

Sandro Galea

[short_description] Policymakers and the media have reacted hastily to COVID-19 research, and not always for the best. Scientific researchers now have new responsibilities to contextualize their findings for the public.

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Inequality and Instability in the Time of COVID-19

Walter Scheidel

[short_description] COVID-19 has widened fault lines between the advantaged and disadvantaged. Yet while many past crises leveled inequality, stabilizers in the modern economy may prevent social and policy reform.

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Digital Contact Tracing in South Korea

Jae Chun Choe

[short_description] South Korea has impressively managed its COVID-19 crisis without lockdowns, roadblocks, or immigration controls. This is only possible given rapid and effective testing and contact tracing systems.

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The Physiology and Biophysics of Respiratory Therapy

J. Scott Turner

[short_description] Though carrying a suite of risks, high-frequency ventilation may be a safer and more effective treatment than the positive-pressure ventilation that is most commonly used in severe COVID-19 cases.

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Cytokine Storms

Tyler Hampton

[short_description] Cytokine storms may be fatal and can occur as a result of many different triggers. A growing body of literature suggests a connection between SARS-CoV-2 infection and the induction of cytokine storms.

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